+30 Who Has The Most Home Runs In One Game References. What is the mlb record for most runs in a game? The 2022 philadelphia phillies joined the 1928 new york yankees, the 1989 oakland a’s and the 2017 astros as teams who hit the most home runs in a single world series.

Five home runs in a game has been achieved. 12 players are tied for the most home runs in a game this season, with 3 home runs. Duvall belted three home runs and drove in nine, homering three times in a game for the second time in eight days.